Galesburg is located just 50 minutes outside the metro Quad Cities.  From Moline, Illinois, take I-74/US-6 E, continue on   I-280 E/I-74 to Galesburg. Take the Seminary Street exit from US-34 W.

Galesburg is located in Knox County, Illinois.

The city is 45 miles (72 km) northwest of Peoria. As of the 2010 census, its population was 32,195. It is the principal city of the Galesburg Micropolitan Statistical Area, which includes all of Knox and Warren counties.

Galesburg is home to Knox College, a private four-year liberal arts college, and Carl Sandburg College, a two-year community college.